Nedavne študije so pokazale, da zdravila za zmanjševanje kisline, znana kot zaviralci protonske črpalke, lahko povečajo tveganje za demenco. Najbolj zaskrbljujoča je ugotovitev, da zaviralci protonske črpalke preprečujejo odstranitev beta-amiloidnih plakov, ki so vključeni v patologijo alzheimerjeve bolezni.
Eden izmed načinov po katerem zaviralci protonske črpalke lahko vplivajo na delovanje možganov je, da zavirajo absorpcijo vitamina B12. B12 je nujen za normalne miselne sposobnosti in vemo, da nizke koncentracije vitamin B12 niso redke pri starejših, četudi ne prejemajo terapije za zmanjševanje »zgage«.
Ker je vitamin B12 tesno vezan na beljakovine, potrebuje dovolj želodčne kisline, da se sprosti za absorpcijo. Zatorej zmanjševanje želodčne kisline z zaviralci protonske črpalke lahko poveča tveganje za pomanjkanje vitamina B12. Priporočljivo je, da si tisti, ki jemljejo večje doze zaviralcev protonskih črpalk dlje časa, redno testirajo koncentracijo vitamina B12.
"When you are healthy, you have a thousand wishes. When you get sick, you only have one."
Chinese proverb
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